Salivary Oxidative Stress Increases with the Progression of Chronic Heart Failure
نویسندگان
چکیده
منابع مشابه
Nitric oxide, oxidative stress, and progression of chronic renal failure.
Cellular injury or organ dysfunction from oxidative stress occurs when reactive oxygen species (ROS) accumulate in excess of the host defense mechanisms. The deleterious effect of ROS occurs from 2 principal actions. First, ROS can inactivate mitochondrial enzymes, damage DNA, or lead to apoptosis or cellular hypertrophy. Second, nitric oxide (NO), which is a principal endothelial-derived relax...
متن کاملOxidative stress and apoptosis in heart failure progression.
The syndrome of congestive heart failure (HF) is the most important cardiovascular disorder in the Western world from public health and health care resource utilization perspectives.1 Great strides have been made in treating patients with HF through the development of drugs that antagonize neurohormonal activation.2 Nevertheless, patients with HF experience clinically meaningful disease progres...
متن کاملNutritional intake and oxidative stress in chronic heart failure.
BACKGROUND AND AIMS Patients with chronic heart failure (CHF) are known to be at risk of malnutrition, and cardiac cachexia is an adverse prognostic indicator. The aim of this study was to determine the dietary adequacy of CHF patients compared with Dietary Reference Values, to compare the nutritional intake and status of CHF patients to a healthy comparison group, and finally to determine whet...
متن کاملOxidative stress and heart failure.
Oxidative stress, defined as an excess production of reactive oxygen species (ROS) relative to antioxidant defense, has been shown to play an important role in the pathophysiology of cardiac remodeling and heart failure (HF). It induces subtle changes in intracellular pathways, redox signaling, at lower levels, but causes cellular dysfunction and damage at higher levels. ROS are derived from se...
متن کاملHeart failure, oxidative stress and allopurinol.
Oxidative stress is one of the new and most intriguing pathogenetic hypotheses of heart failure; it involves various mechanisms such as endothelial dysfunction, mechano-energetic uncoupling and apoptosis. Xanthine oxidase, a key enzyme in purine catabolism, is overexpressed in patients with heart failure, and it is also an important source of oxidizing activity molecules (free radicals, superox...
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ژورنال
عنوان ژورنال: Journal of Clinical Medicine
سال: 2020
ISSN: 2077-0383
DOI: 10.3390/jcm9030769